Identification and Characterization of Cancer Stem Cells Using Flow Cytometry
نویسنده
چکیده
Tumors are heterogeneous in their cellular morphology, proliferation rate, differentiation grade, genetic lesions, and therapeutic response. The cellular and molecular mechanisms that cause tumor heterogeneity are largely unknown. Growing evidence suggests that tumors are organized in a hierarchy of heterogeneous cell populations and are made and maintained from a small population of stem/stem-like cells called cancer stem cells (CSCs). CSCs are defined on the basis of characteristics such as high tumorigenicity, self-renewal, and differentiation that contribute to heterogeneity. Cancer recurrence is thought to be due to CSCs that are resistant to chemotherapy and radiation.
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